Endocrine Abstracts

Introduction: Chronic liver disease (CLD) is usually not described as a common cause of hypercalcemia unless there is hepatoma. Of late, there are some reports suggesting CLD as a cause for hypercalcemia. The exact mechanism contributing to hypercalcemia in CLD is poorly understood. It usually correlates with the severity of disease.Aim of the study: To assess the prevalence of hypercalcemia in patients with chronic liver disease To study the relation of...

Introduction: Familial isolated pituitary adenoma (FIPA) and young-onset sporadic pituitary adenoma patients are suggested to be screened for mutations in AIP, a gene described in 2006 and amenable to UK testing since 2008.Methods: affected subjects have been tested in Exeter and Oxford genetic laboratories. Data were collected from 120 FIPA-families and 193 sporadic cases with young-onset disease (<30y) from 49 centres in the UK. The Mann&#...

Background: A founder mutated AIP allele, R304* was previously identified in several Irish familial isolated pituitary adenoma (FIPA) pedigrees from a small region within Mid Ulster, Northern Ireland, but the allele’s general population impact remains unknown.Aims: To estimate R304* prevalence in the general population and pituitary adenoma (PA) patients and to calculate the allele’s time to most recent common ancestor (tMRCA).<p c...